Although eNOS is an important player in regulating vascular function with anti-atherogenic properties [47, 48], reports on its role in hypercholesterolemia are mixed: Hypercholesterolemia was reported to upregulate eNOS expression in the rabbit aorta [49], while it may be functionally compromised and contribute to endothelial dysfunction in CAD patients [50].
In vivo, pathogen-infected APCs may be functionally compromised and DCs may not be directly infected.
The A1708E variant acted as a positive control for functional assays since we and others [ 3, 9, 13] have previously shown this variant to be functionally compromised.
CD8low cells are characterized by an activated phenotype, are functionally compromised in vitro, and are slated for deletion in vivo.
However, in some other conditions, TIDCs are functionally compromised.
In contrast to these latter variants, our data suggest that the G787R variant is functionally compromised and may be a rare cause of hereditary colorectal cancer.
Moreover, there are pathological conditions, such as Dent's Disease and Lowe Syndrome, in which megalin expression is functionally compromised [14], [63], [64].
If the cells are functionally compromised, their reabsorption rate will decline.
A number of different approaches have been taken to the question of why D2 alleles are functionally compromised, whereas D1 alleles are not.
Although circulating thyroid hormone levels were low, liver enzymes responsive to thyroid hormone levels were elevated, suggesting that thyroidal homeostasis was not functionally compromised.
