MEF2C is expressed in neurons in regions that are functionally affected in HAND, including the frontal cortex and hippocampus.
The study also indicates that the ductal epithelium is functionally affected in some pSS patients, which calls for future pathophysiological studies on the mechanisms underlying this impaired salt reabsorption.
Phototoxicity and cell viability were documented by the MTT assay (Denizot and Lang, 1986), a method based on the activity of mitochondrial dehydrogenases, which will be functionally affected by PDT in vitro (Hilf et al, 1984).
Accumulating evidence reveals that without activation, CAR forms a protein complex in the cytoplasm where it can be functionally affected by multiple signaling pathways.
Many mitochondrially localized proteins involved in the apoptotic process are functionally affected by phosphorylation, which can ultimately dictate whether a cell lives or dies [ 112].
This area is believed to be an important component of the default mode network, a network that is structurally and functionally affected in normal aging and more prominently, and very early, in AD [ 34– 34].
These links between the SR and excitability in smooth muscle are considered to be functionally important and affected by disease such as hypertension and dyslipedaemia [25,30].
To determine whether these samples were indeed functionally affected, additional analyses of the in vitro apoptotic response to various DNA-damaging agents, that is, fludarabine, doxorubicin and irradiation were performed.
In mammalian cells, Dcr enzymes are required for RISC assembly as well as dsRNA processing, suggesting that the two phases of RNAi might be functionally coupled in a manner that affects siRNA strand selection.
