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Alternatively, elevated circulating lyso-PCs may not be functionally active in this process but represent activated pathways in the synthesis or metabolism of phospholipids and phosphatidylcholine and, thus, in the generation of hepatic endoplasmic reticulum stress (40) (Supplementary Fig. 2).
In addition oral administration of TGF-β has proven to be functionally active in the intestine when using a mouse model [55].
Recombination proficiency of the wild-type and mutant RecBCD enzymes were then assessed by the Hfr conjugational crosses, and in mixed phage lambda infection assays in V67 (recB21::Istrainstrain of E. coli as shown in Table 3. RecBCDPs was found to be functionally active in E. coli.
CNV are shown to be functionally active in humans.
The ERG subfamily includes TFs such as ERG and FLI1, which are known to be functionally active in HUVEC.
Taken together, these results support the presence of PIPKIγ_i4 in the nucleus and suggest that PIPKIγ_i4 could be functionally active in cytoplasmic as well as nuclear processes.
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Consistent with this localization, TLR2 is functionally active in synovial fibroblasts and endothelial cells, where its activation results in induction of VEGF, IL-8, ICAM-1, VCAM-1 and MMPs [ 15, 21, 22, 27- 29].
Both the longer and shorter isoforms contain the major functional domains of the protein, including the GTPase domain, and are functionally active in biochemical assays [ 29, 36].
These results were consistent with the idea that OsNCED4 is functionally active in ABA biosynthesis.
Like OsNCED3, OsNCED4 is functionally active in ABA biosynthesis in rice.
In this study, reverse genetic approaches were used to determine if rice OsNCED4 is functionally active in ABA biosynthesis.
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