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Receptors proved to be functionally active as human and pig chondrocytes attached to RGD-coated surfaces.
Corresponding motifs of HAdV-C2 play an important role in directing cytoplasmatic proteins to the nucleolus and thus might be functionally active as nuclear localization signals [ 49].
The use of antibodies to other motifs in CCN3 will permit us to track the cleaved N-terminal peptide which potentially could be functionally active as it resembles IGFBP [ 1].
Within these cells, Nrf2 appeared to be functionally active, as indicated by the expression of HO-1 in the same cells and the selective up-regulation of other Nrf2-responsive genes in microdissected lesion areas with initial stages of demyelination and tissue injury.
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Similarly, iNOS protein was detected from 24 to 72 h and de novo synthesized iNOS was functionally active, as measured by Ca2+-independent NOS activity.
In reconstituted photolyase the F0 chromophore is functionally active as judged from the increase in the in vitro repair activity.
The introduced MKK7 was functionally active, as its overexpression in 293T cells was capable of inducing the activating phosphorylation of JNK (Fig. S5).
Purified enzyme was functionally active as determined by in vitro prenylation and phosphoisoprenoid binding assay.
Our data clearly demonstrate that CFTR is expressed and it is functionally active as a Cl− channel in monocyte-derived macrophages isolated from healthy donors.
Figure 1C demonstrates that the TG present in aortic homogenates is functionally active as proteins readily incorporate the biotin-linked amine donor pentylamine biotin (+BAP), compared to samples that had no amine donor (−BAP).
The Perforin-2 fusion proteins were functionally active as shown above in complementation studies.
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