In the present study, we show that the Wnt/β-catenin pathway is functionally activated in mammary tumors induced in the BK5.ATF3 model.
In conclusion, our findings show that the Notch signalling system is functionally activated in human osteosarcoma.
Autophagy is functionally activated in HCC cell lines after oxaliplatin treatment, and suppression of autophagy enhances oxaliplatin-induced cell death.
The substrate of FM lies in the pain system, which can be functionally activated by distress, a common feature of chronic painful and disabling disorders.
Thus, only nuclear NF-κB is considered to be functionally activated.
P53 is known to be functionally activated prevalently by protein stabilisation, hence its accumulation was monitored.
Analysis of FTL expression in the retinas of mice following diurnal exposure to light shows that bipolar cells, specific classes of amacrine cells, ganglion cells, and a dense network of processes in the inner plexiform layer are functionally activated.
Fully differentiated neutrophilic granulocytes are functionally activated by G-CSF [ 1– 4].
Alternatively, elevated circulating lyso-PCs may not be functionally active in this process but represent activated pathways in the synthesis or metabolism of phospholipids and phosphatidylcholine and, thus, in the generation of hepatic endoplasmic reticulum stress (40) (Supplementary Fig. 2).
A logical prediction of this hypothesis is that in order for Net1 to be functionally active, it must be transported out of the nucleus into the cytosol, where it can activate RhoA.
