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The paper is an example of applied product design, with the aim of producing strong granules with sufficiently low binder content so as to be functional within the ceramic industry.
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Although deletion and mutation analyses revealed that all SBE's are functional within the context of the natural AmphiVent1 promoter, only the cluster of proximal SBE's can function as an autonomous BRE when fused to a heterologous promoter (Fig. 2D).
Our cell culture results confirmed that the gene network predicted from the microarray analysis is functional within the hypothalamus.
Furthermore, we previously demonstrated that KRAB/KAP-mediated repression is functional within the context of episomal DNA (Barde et al., 2009).
Thus, although Giardia possesses a full complement of these proteins, other than Ski7, we can't yet conclude that NSD and/or NGD are functional within the parasite.
But the Advanced LIGO (aLIGO), which should be functional within 3 years, is on the horizon.
Although the function of this family is unknown, each member has a large complement of predicted transmembrane domains, indicating that they are functional within one of the cellular membranes.
The notion that NOD2 is functional within brains is supported by the observation that this gram-positive CNS pathogen simultaneously elicits increases in the levels of NF-kB protein, which is an essential downstream effector molecule of NOD2-mediated immune responses.
Finally, it should be noted that a small minority (~10%) of RidA proteins have a serine residue instead of arginine, suggesting there may be functional diversity even within the RidA subfamily.
These results imply that there can be functional differences within an operon depending on the actual transcriptional boundary and that the differences can also influence genome organization.
The substrates of the BER glycosylases overlap and therefore there is functional redundancy within the oxidative DNA damage repair system.
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