Sentence examples for be functional regulators of from inspiring English sources

Those observations indicated that the miRs we identified in the present study might be functional regulators of the migration and metastasis of breast cancer via regulating Cx43 expression.

These findings suggest that expression of pseudogenes lncRNAs are actively regulated and constitute functional regulators of inflammatory signaling.

While false-positive prediction rates remain high for many studies, when CRMs are positively identified by these methods, it is assumed that the TFBSs that were used as input to the prediction algorithm are important functional regulators of the CRM's activity, as are the transcription factors that bind to these sites.

Altogether, these results suggest that ploidy can be a functional regulator of the senescence program.

To test our hypothesis that AFAP1L1 would be a functional regulator of vinculin, we finally examined whether AFAP1L1 could alter the apoptotic status.

The KIRs are the main functional regulators of NK cells; the activity of these effector cells is determined by the balance between their activation and inhibition that occurs as a result of the binding of KIRs with HLA class I molecules present in all nucleated cells [ 7].

To test whether the identified forkhead element was a functional regulator of the promoter and whether it could explain the increased stimulation of PII −516bp-luciferase by the FOXL2 C134W (Fig. 2) we generated a mutant version of the reporter, in which the putative element was mutated in the same manner as in the EMSA probes above.

Interestingly, the present study revealed that URI was a functional regulator of IL-6 transcription in MM.

Sirt1 is a functional regulator of PGC-1α that induces a metabolic gene transcription program of mitochondrial fatty acid oxidation [ 24].

The next step will be to identify if these functional regulators of drug sensitivity can improve the prediction of chemosensitivity in prospective studies and whether they can be successfully combined with prognostic methods to guide the selection of appropriate chemotherapy regimens in a 'personalised' approach to improve patient outcome.

Nearest, piRNAs were reported as functional regulator of enhancing long-term synaptic facilitation through silencing CREB2 [ 65].