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The third γ-GT was only distantly related to the others and may not be functional owing to the presence of mutations in the active site.
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It is more likely that these samples were labeled functional owing to redundancy of the ATM-kinase activity in the remaining allele, in line with previous studies showing that CLL samples with both ATM alleles affected (either deletion and mutation or two mutations) lack ATM activity, while patients with monoallelic lesions may have preserved ATM function.
Short SSU rRNA sequences have previously been reported from empty circle 4, but they were believed to be non-functional owing to their length [ 15].
Similarly, the fusion protein comprising GFP linked to a mutant full-length version of DdFDPS GFP in which the PTS2 sequence was non-functional owing to replacement of the initial arginine residue with an alanine residue (R8A) accumulated in the cytosol, although some was able to localize to peroxisomes.
Many of these gene segments are annotated as non-functional owing to defects in their primary sequence, the absence of motifs necessary for rearrangement, or chromosomal locations outside the TCR locus.
That mentality; things have to be functional".
It was too big to be functional.
It had to be functional.
It has to be functional".
Is the bong meant to be functional?
"The point is there are functional equivalents to jungles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com