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Moreover, the genomes of such alphaviruses can be engineered to contain RNA elements that would be functional only in cells of vertebrate, but not insect, origin.
For example, some nuclear receptor binding sites may be functional only in a tissue-specific or developmental-time specific manner, and subordinate to chromatin modifications that occur at a certain stage of cell fating, during development, aging or disease state.
Many lncRNAs may be functional only in simians.
This gene encodes a regulator of chromatin binding factors thought to be functional only in males.
This result, together with the finding that ANRIL contains only a few exons in mammals, suggests that ANRIL may be functional only in simians.
The PZ also encompasses the trpRBA operon, which has been found to be functional only in genital isolates, and to carry mutations in ocular strains [ 27].
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An instance of the KDEL motif, which is an endoplasmic reticulum retrieving signal, is likely to be functional only if present in protein sequences known to localise to the ER or Golgi apparatus.
The e y 2 retrogene in Drosophila melanogaster performs a general function and is ubiquitously expressed, while the source gene e y 2b is functional only in a small group of male germ cells [ 16].
MAMMALS are named after their defining characteristic, the glands capable of sustaining a life for years after birth — glands that are functional only in the female.
Using high-throughput genetic engineering, we resized the arm in the range of 6 60 nm and found that it was functional only in specific length regimes following a periodic pattern.
We have previously shown that phenotypic allelic exclusion of TCR alpha-chain is functional only in mature thymocytes.
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