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Note that the conserved functional regions defined above may not be functional in mouse.
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Currently, a total of 13 TLR genes have been identified in human and mouse genomes; TLR1 10 are functional in human, and TLR1 9 and TLR11 13 are functional in mouse.
Therefore, this work establishes that the molecular mechanisms involved in the regulation of gene transcription by amino acid availability are functional in mouse liver.
Therefore, this work establishes for the first time that the molecular mechanisms involved in the regulation of gene transcription by amino acid availability are functional in mouse liver.
We confirmed thatΦC31integrase was functional in mouse A9 cells, and the MI-HAC vector with ΦC31integrase can be applied as an efficient gene expression system in various cell environments.
Due to their role in epidermal homeostasis and early response to keratinocyte damage, we investigated whether skin γδ T cell are functional in mouse models of obesity and metabolic disease.
Moreover, we thank the referee pointing out the typo regarding P2X channels; we have made some clarifying changes to the respective sentence: "purinergic P2X channels are functional in mouse (Navarro et al., 2011), but not in human sperm (Brenker et al., 2012)".
To assess whether the "Leu3p-α-IPM" expression system is functional in mice, we generated transgenic mice expressing Leu3p ubiquitously under the control of the SV40 promoter (L3).
For example in mice 12 TLRs are known [ 78], but only 9 of the TLR1-10 which are common in most mammals are functional in mice.
Surprisingly, this strain appeared to be functional in the mouse model of infection.
The present report focused specifically on genes that have been shown to be functional in the mouse oocyte model (Supplemental Table 3).
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