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In conclusion, patients affected by type 2 diabetes are under condition of systemic oxidative stress and, although the relevance of downregulation in sirtuin signal has to be fully understood, however induction of HSPs and thioredoxin protein system represent a maintained response in counteracting systemic pro-oxidant status.
Philolaus' explanation of the cosmos in terms of limiters and unlimiteds cannot be fully understood, however, without discussing his third basic principle, harmonia.
The pathophysiology of sepsis is yet to be fully understood; however, current understanding of the development of sepsis-induced MOD highlights the involvement of various cell populations and cell signaling pathways in the onset of this condition, leading to a systemic, sometimes excessive, immune response to an infection.
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The nature of good indexing was still far from being fully understood, however, and it was only later in the 19th century that really good encyclopaedia indexes were prepared.
The mechanism underlying the antifibrotic action of RLX is still far from being fully understood; however, the polypeptide hormone has been shown to reduce the activity of some pro-fibrotic factors (i.e. transforming growth factor-β1 and interleukin-1β) [ 35, 36] and to cause MMP production in some tissues [ 37].
He said he could remain on bail in the meantime, but warned: "It must, however, be fully understood that in terms of the ultimate sentence, nothing must be read into that".
The current mechanisms linking ER stress activation to neuronal cell fate upon chronic or acute stresses remain however to be fully understood.
The impact of flow conditions on the toxicity pattern of the polarity-differentiated classes of toxic xenobiotics in the influent and effluent of the STP Trier could however not be fully understood.
However, to be fully understood, the precise mechanism of miR-146a action (its specific gene targets) in prostate cancer progression warrants investigation.
The breadth and importance of the protein targets, however, remains to be fully understood.
Mr. Obama's statement was fully understood by his ultra-liberal base, however.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com