The origins of this emergent infectious disease have not been fully understood, although it was originally thought to arise mostly from human behavior and work practices (10 ).
However, despite the increasing evidence of polyploidization as a major force in evolution, the molecular basis of diploidization is far from being fully understood, although many mechanisms have been suggested to date.
The mechanisms underlying an increase in urinary DiAcSpm value in cancer patients have not been fully understood, although a considerable amount of literature has reported the usefulness of urinary DiAcSpm as a novel tumor marker.
Although these interrelated puzzles have been extensively studied for many years, neither is fully understood.
Exactly how this is achieved is not fully understood, although several regulatory systems are involved including the RANKL/OPG axis, LRP5/Wnt signaling and more recently purinergic signalling.
How the effect of helix1 on the C-ABS is regulated is not fully understood although recent work suggests that there may be a functional link between the C-ABS and IBS2, the integrin-binding site located in the talin rod (Himmel et al., 2009).
Why a seemingly blameless activity like sitting should be detrimental to health, even for those of us who work out, is not fully understood, although it is assiduously being studied at many labs.
The cause of his condition is not fully understood, although it is thought to be passed on genetically.
The mechanism of action is not fully understood, although it is thought to be a DNA intercalator.
