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Clearly the argument that it cannot be fully known whether new treatments are safe until they are tried in human beings is correct but it is questionable whether the appropriate comparator was addressed by the Panel.
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Hyphens, quite simply, refuse to be fully known.
Where we could be fully known and fully understood every once in a while.
"We are specifically concerned as to whether the extent and breadth of the practice is fully known, and whether this odious practice is ongoing within the construction industry," Davidson added.
Regardless of whether the causes are fully known, Sage Therapeutics believes it has tapped into a novel way of treating the most severe cases of PPD by targeting the brain's GABAA receptors with an infusion of brexanolone.
It is assumed that this is fully known.
However, it is not fully known whether heterogeneous cancer stem cells exist in the many types of solid tumors and how this heterogeneity may affect treatment response of these cancers.
It is not fully known whether the bone loss starts immediately after the operation or after a few weeks.
It is still not fully known whether changes in SPD features would affect the emotional and psychosocial function of individuals with SPD, both at the clinical and psychometrically-defined levels.
What is not fully known is whether this observation is evidence of a rhythmic expansion and contraction of the star's photosphere as astronomers have theorized, and if so, what the periodic cycle might be, although Townes suggested that if a cycle does exist, it is probably a few decades long.
"It's premature to begin discussing specific legislative fixes," he said, "when we don't fully know whether the problem exists".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com