The predictive value of neither type of model has been fully established; however, there is agreement that molecular characterisation of all tumours is required to underpin the choice of model.
Aetiology for sarcoma development has not been fully established; however, variations between ethnic groups in the incidence of rhabdomyosarcoma and fibrosarcoma, together with their occurrence in a number of heritable syndromes, suggest that genetic predisposition is important [ 4].
Why patients with COPD have increased aortic PWV has not been fully established, however they have multiple risk factors for CV disease including a history of cigarette smoking, physical inactivity, nutritional and metabolic abnormalities as well as airflow obstruction [ 35].
The metabolic function of apolipoprotein A-IV (Apo A-IV) has not been fully established, however it has been suggested that Apo A-IV plays an important role at early life, modulating the enterocyte lipid transport efficiency in fatty foods, namely colostrum [ 27].
However, it has not been fully established yet whether the mediator of these effects is telomerase inhibition per se or telomere shortening resulting from inhibition of telomerase activity.
Chronic deflation, however, may only be fully established in the recovery to follow.
Recent studies have indicated a link between nucleoporin RanBP2/Nup358 and chromosomal segregation during mitosis; however, the molecular details have yet to be fully established.
However, the causal relevance of many predictive biomarkers of CVD has yet to be fully established, but this may not necessarily be required for risk prediction.
