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Whether this was a class effect or a compound-specific off-target effect remains to be fully established, although reports that GPR40 is not expressed in hepatocytes and that TAK-875 impaired the function of bile acid-related transporters lends hope to the idea that structurally unrelated GPR40 ligands might not similarly target the liver [ 3, 25].
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The effect of condom use in preventing HPV transmission and infection has not been fully established, although more studies have suggested a protective effect [ 22].
For immunocompetent patients in India it is 98.8% and 97.6% sensitive and specific respectively [ 13]; its accuracy in immunocompromised patients had not yet been fully established although is likely to be lower.
Pleione is known to be a speckle binary, although its orbital parameters have yet to be fully established.
Progesterone receptor is a fundamental orchestrator of breast development and function [29], but is also implicated in breast cancer development and progression, although its role in these processes is still to be fully established [1].
What this truly means is yet to be fully established.
We do not know who her mother was: her ethnic inheritance can't be fully established.
Expected to be fully established by end of 2015.
Spread of resistant viruses could limit the efficacy of current therapeutic interventions using these same drugs, although it should be noted that the fitness of multidrug resistant viruses for mucosal transmission has yet to be fully established.
Braces and orthotics can also be effective, although evidence for the efficacy of these measures has yet to be fully established in clinical trials.
Although it is now indisputably accepted that neurogenesis occurs in the adult brain, its functional relevance remains to be fully established.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com