Sentence examples for be fully elucidated it from inspiring English sources

Although the function of glucocorticoid-induced tumor necrosis factor receptor related protein (GITR) remains to be fully elucidated, it is generally accepted that GITR expression is increased upon TCR engagement, reflecting T cell activation [42].

6 The pathophysiology of pain in CP has yet to be fully elucidated; it is probably of multifactorial origin.

Although the specific biological mechanisms that affect feed efficiency have yet to be fully elucidated, it is likely to be controlled by a combination of factors including physiological [ 6- 8], genetic [ 9- 11] and behavioral mechanisms [ 3, 8, 12].

Although the precise role of arrestins in the regulation of mu-opioid receptors in neurons remains to be fully elucidated, it may explain the observed ligand-specific effects in the present work and others.

Although the exact molecular mechanisms have yet to be fully elucidated, it is clear that incision around the lesion to allow 'unhooking' of the ICL from one of the two DNA strands represents a pivotal step in the repair process as it relieves the torsional stress an ICL imposes on the DNA helix and permits processing of the repair intermediates by downstream pathways.

Although the specific functions of MeCP2 that become compromised due to these specific mutations remain to be fully elucidated, it is clear that deficits in proper MeCP2 function can lead to impaired neural network function and cause pronounced neurological and behavioral phenotype impairments.

Although the best strategy to prevent the progression to ARDS has not been fully elucidated, it is clear that its prevention should be a high priority in clinical care and further research [ 58].

While the direct mechanisms of neurodevelopmental toxicity have not been fully elucidated, it is conceivable that alterations in thyroid hormone levels in the developing brain may contribute to these effects.

Although the mechanism of hypercoagulability in patients with cancer has not been fully elucidated, it is thought that tumour cells express tissue factors that activate the coagulation cascade, including cellular procoagulants such as tumour procoagulant and factor X receptors.

While the mechanisms of simvastatin-induced myopathy have not been fully elucidated, it is likely that simvastatin induces myopathy by disrupting isoprenoid intermediates in the cholesterol synthesis pathway.

Although the etiology of IBD has not been fully elucidated, it is well known that IBD is closely associated with an abnormal response to the normal gut flora caused by the loss of intestinal barrier [3], [4].