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The biochemical properties and physiological functions of the PSGs remain to be fully elucidated, although functional experiments and clinical observations are beginning to provide some clues.
At present the impact of these differences in binding affinity on the interpretation of the PET signal remains to be fully elucidated although it may be expected that low-affinity binding sites should lead to an underestimation of TSPO.
The function of these nucleolar caps within the DDR has yet to be fully elucidated, although PML has been shown to influence p53 activity by sequestering MDM2 at the nucleolus.
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The mechanisms of rituximab resistance have not yet been fully elucidated, although both tumor- and host-associated resistance mechanisms have been proposed.
For most antimalarial drugs neither mode of action nor mechanisms of resistance development are fully elucidated although this would be important prerequisites for successfully developing urgently required novel antimalarials.
This observation is important, but has not been fully elucidated although it is in line with observations made in two previous analyses.
PGP's aetiology is still unknown and the underlying mechanisms have not been fully elucidated although mechanical, traumatic, hormonal, metabolic, and degenerative factors have been proposed [ 1, 2].
Signaling pathways influenced by PDT have not been fully elucidated, although a number of studies have addressed this issue [ 5, 10, 19].
The mechanism by which ATEN lowers BP has not been fully elucidated, although it is thought that the primary mechanism is through reduced cardiac output via a reduction in heart rate.
The patho-mechanisms of chemotherapy-related oral mucositis have not been fully elucidated, although considerable progress has been made during the last decade in defining a cascade of destructive and inflammatory events [ 3].
The molecular mechanisms of DNA methylation mitotic stability have not been fully elucidated, although the high affinity of the DNMT1 protein complex for hemi-methylated DNA appears to be involved in this process [ 7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com