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Thus, we believe that patients with the ATG16L1*300A allele are likely to be fully competent for the homeostatic functions of autophagy, yet may exhibit altered responses to bacterial components and infection in the gut milieu, where antigen burden is high.
Thus, stricto sensu, platelets do not appear to be fully competent for phagocytosis and their trapping of infectious pathogens remains unsolved.
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Taken together, the extended conformation of a PKS module is fully competent for all of its essential catalytic functions.
In vitro kinetic analysis proved that this antibody stabilized module conformation was fully competent for catalysis of intermodular polyketide chain translocation as well as intramodular polyketide chain elongation and functional group modification of a growing polyketide chain.
She was fully competent for the job, [even] having never done it before.
In contrast to Notch1 receptors, S1-resistant Notch2 receptors are fully competent for cell surface delivery and for activation by ligands.
We employed a non-immortalized, non-transformed primary fibroblast cell line that is fully competent for IRF3 signaling and is susceptible and permissive to infection by HSV-1.
Whereas the topoisomerase monomer is fully competent for strand cleavage, the Cre monomer likely requires allosteric activation by a neighboring monomer to become cleavage proficient [3], [6].
These results imply that mutations at positions 313 and 314 that do not inhibit formation of stable channels are fully competent for protein translocation.
However, Notch1 and Notch2 receptors engineered to resist S1 cleavage exhibit unexpected differences in surface delivery and signaling competence: S1-resistant Notch1 receptors exhibit decreased, but detectable, surface expression and ligand-mediated receptor activation, whereas S1-resistant Notch2 receptors are fully competent for cell surface delivery and for activation by ligands.
As shown here, in S. rostrata symbiotic nodules, haploid A. caulinodans bacteroids carrying single knockout alleles in either exo- or-endo-hydrogenase structural genes, like the wild-type parent, evolve no detectable H2 and thus are fully competent for endogenous H2 recycling.
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CEO of Professional Science Editing for Scientists @ prosciediting.com