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The signalling mechanisms underlying these designs remain to be fully characterized although shear stress, wall tensile stress and metabolic stimuli are likely candidates.
Due to its relatively recent discovery, this group has yet to be fully characterized, although it is evident that this population is a very heterogeneous one.
Identification of kcnqx potassium channel transcripts in zebrafish (Danio rerio) remains to be fully characterized although some genes have been mapped to the genome.
The mechanism of action of ECT still needs to be fully characterized, although several hypotheses have been conceived, involving neurotransmitter systems (Yatham et al. 2010), endocrinological pathways (Kunugi et al. 2006), and neurogenesis (Nibuya et al. 1995; Madsen et al. 2000).
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The target(s) of such antibodies have not been fully characterized, although several antigens have been suggested [ 38, 39].
Type II sites have not been fully characterized, although histone H4 binds type II ligands and is thought to be the type II site (Markaverich et al. 2001; Shoulars et al. 2002, 2005).
The mechanism of action for how estrogen may act as a neuroprotective agent following TBI has not yet been fully characterized, although it has been hypothesized that estrogen acts on target cells including G-protein-linked estrogen receptor 1 (GPER) and one recent study reported acute protective effects of GPER post-TBI (Arevalo et al. 2015).
The functional role of the SRCR domains in LOXL2 4 proteins has not yet been fully characterized, although they could be involved in protein protein interactions and ligand binding in both soluble proteins and membrane-bound protein receptors (Hohenester et al., 1999; Martínez et al., 2011).
However, it should be cautioned that more detailed clinicopathologic characteristics for subtype 2 DLBCL patients as defined by either gene subset G2 or G4 have to be fully characterized before use although the survival profiles for the subtype can be clearly separated from other two subtypes.
Although PA stimulates a complex inflammatory response, the specific contributions of different mediators in the host-defense against this bacterium have yet to be fully characterized.
Although there is distinct evidence that NT-proBNP might also be altered following trauma, the early dynamics of NT-proBNP in severely injured patients developing organ failure has yet to be fully characterized [ 4, 5].
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