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In contrast, information on new, rare or long-term adverse effects are unlikely to be found in trial reports.
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A drug called Truvada has been found in trials – when used as a pre-exposure prophylaxis (PrEP) in HIV negative people at risk of getting the virus – to reduce the transmission of HIV, but has not yet been approved or funded by the NHS for this.
While the quality of feed index (Iqf) 90.63%, multiple index (Imult) 0.94%, missing index (Imiss) 8.44% and precision index (Ip) 17.63% were obtained in trials performed by the EMDS, Iqf 88.13%, Imult 2.50%, Imiss 9.38% and Ip 17.81% were found in trials performed by the CDS.
The Lancet report pointed to Dendreon's Provenge prostate cancer treatment -- which costs more than $100,000 for a three-dose course and was found in trials to improve survival by several months in patients with few other options.
Initial hits were found in trials of sample containing PPIL1, CsA and SKIP44 74.
In the last year, a population level behaviour change intervention was found to be ineffective [15] and risk compensation and low adherence may have contributed to no effect being found in trials to prevent HIV infection through diaphragm use [16] and herpes treatment [17], respectively.
No evidence of effect was found in trials including only surgical ICU patients.
No intervention effect was found in trials that performed systematic HCC screening.
However, a statistically significant and clinically meaningful (>1 day) difference in weaning duration was found in trials of mixed and medical ICU populations and SmartCare/PS™.
Eligibility criteria for the trial can be found in the trial report [ 5, 6].
More detail of the trial CMHT and practice participants can be found in the Trial report [ 18].
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