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Hepatofugal flow of the portal vein, which can be found in severe portal hypertension or Budd-Chiari syndrome with large extrahepatic portosystemic collaterals, has not been reported in post-Fontan patients [63, 66, 70, 73, 74, 75].
Based on the findings above, LGT can also be found in severe TBI patients' serum, and it may be the early warning sign for disease aggravation or even death.
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Furthermore, a higher prevalence of mutated Pf-dhfr isolates was found in severe cases.
Certain amino acid changes in the hemagglutinin molecule observed in the present study and by others [3], [4], [5], [6] have been found in severe cases (Table 1).
Figure 5A depicts the model structure of HA protein, highlighting the amino acid substitutions at positions 156 and 185 that were found in severe cases, as described above.
A lower proportion of parasitaemia was found in severe malaria cases than in MM in contrast with previous studies conducted in this area, before the appearance of chloroquine and sulfadoxine-pyrimethamine resistance [24].
Moreover, increased airway epithelial IL-33 protein expression was found in severe asthma [ 17].
The highest frequency of CD4+CD28null T cells is found in severe RA, particularly in patients with rheumatoid vasculitis [ 11, 16].
Depressed levels of C3 were found in severe and uncomplicated malaria as compared to healthy controls [ 12, 99].
Early work by Marsh and others established that three overlapping syndromes were found in severe disease: cerebral malaria (CM), respiratory distress (RD), and severe malaria anemia (SMA).
Not surprisingly, high HBP plasma levels are found in severe sepsis patients and in septic shock patients as well as in serious infections associated with endothelial damage.
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