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The often employed Monte Carlo Methods take only a tiny fraction of the whole sequence space into account, and in most cases a less than optimal solution with respect to the theoretically ideal combination of codons representing the desired properties will be found in reasonable time.
Although it is an NP-hard problem, exact solutions can be found in reasonable time even for large instances (see in Section 6 the computing times for instances up to 5000 items).
When the GNA is more complex, e.g. matched pairs are not limited to belong to the same Inparanoid clusters, or the PPI networks have more edges, then our MP algorithm cannot be used and the optimal matching cannot be found in reasonable time anymore.
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Subsequently, the "good" solution may not be found in a reasonable time.
The planning problems can be solved by lingo optimization method (exact solution), but cannot be found in a reasonable amount of time for problems of large size.
Computational experiments demonstrate that optimal solutions for problems with up to 40 nodes can be found in a reasonable amount of time.
We then propose a number of heuristic algorithms with worst case linear execution complexity that can be used when an optimal solution cannot be found in a reasonable time.
While some saddles are quite expensive, others can be found in a more reasonable price range.
This view, he suggested, could be found in Butler's claim that "Reasonable Self-love and Conscience are the two chief or superior principles in the nature of man," each generating an obligation, though Frankena (1992) and Darwall (2000) have raised questions about the historical accuracy of this attribution.
Cream shadows can be found in any drugstore, usually at a reasonable price.
A reasonable explanation should be found in the molecular weight between chain entanglements (Me), which has been estimated at 60,000 for PIOA, much higher than Me for the traditional polydiene central blocks in the well-known thermoplastic elastomers of the triblock type.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com