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This level of statistical power to exclude randomness as an explanation is not to be found in randomised controlled trials (RCTs).
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BCG, DTP and MV have different effects on survival, and since BCG and MV have been found in randomised trials to have a beneficial NSE, DTP apparently has a negative NSE.
The answer cannot be found in this small non-randomised, incompletely matched cohort study, particularly since substitution of bicarbonate in the circuit prime failed to eliminate exposure to supra-physiological concentrations of acetate and gluconate, for reasons already discussed.
Thus, similar changes during MPH treatment can be found in treatment-naïve groups in both randomised controlled trials and observational trials.
However, the identified evidence for this conclusion was identified as weak [ 16]: larger effect estimates were found in non-randomised trials than in randomised studies of the same intervention and measured outcome.
No difference in mortality at 2 years was found in one randomised trial comparing transcatheter valve versus surgical replacement.
Similar results were found in a randomised controlled trial on medical students' reaction to feedback (Boehler et al., 2006).
No major differences in complication rates between insertion of a disc prosthesis and fusion have been found in a randomised setting.
Similar data were found in the randomised PRIME study, investigating the addition of panitumumab to oxaliplatin also in the first-line setting (Douillard et al, 2010).
For antibiotics and cholesterol, no additional effects were found in the randomised study of GPs with a greater involvement (table 2).
A statistically significant increase in OS was found in the randomised CONKO 003 phase III trial with oxaliplatin combined with an 5FU regimen as the second line of treatment, compared with the best supportive care.
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