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Accordingly, fungal macromolecules including polysaccharides, proteins and DNA can be found in peripheral blood, cerebrospinal fluid and brain tissue of AD patients53, 54, indicative of disseminated fungal infection.
While the prion mRNA and protein are detected primarily in the CNS, it can also be found in peripheral tissue.
Studies should therefore include multiple sampling points, and at times of infection/immunisation when the B-cell phenotypes of interest are likely to be found in peripheral blood.
Proviral DNA can readily be found in peripheral blood mononuclear cells.
High levels of circulating FASN can be found in peripheral blood of HER2-overexpressing BC patients [ 4].
EpCAM as well as cytokeratin expressing cells can be found in peripheral blood of advanced cancer patients but are rare in healthy donors [ 1, 10].
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A statistical trend to greater CD44 expression was found in peripheral epithelial cells of complex adenomas, benign mixed tumours and complex carcinomas compared with simple carcinomas.
Lastly, the analyst assessed the existence of tumor-in-normal contamination for example, when leukemic blasts are found in peripheral blood by examining the mutant allele fraction (MAF) of likely somatic mutations in the germline WGS and WES samples.
Using MALDI-TOF MS, increased DNA methylation levels of SMAD7 promoter at CpG unit 5.8.15.16 were found in peripheral blood of atherosclerosis patients relative to matched normal controls, respectively.
Clinical studies suggest that hypercholesterolemia may cause ageing in hematopoietic stem cells (HSCs) because ageing-associated alterations were found in peripheral blood cells and their bone marrow residing precursors in patients with advanced atherosclerosis.
Furthermore, neuronal and non-neuronal expression of the α7 nAChR has also been found in peripheral organs [6],[10], and the receptors were proposed to be involved in the development of cancer [8],[8]].
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