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Other examples of EMT associated with therapy resistance can be found in bladder cancer [15], lung cancer [16], prostate cancer [17], and hepatocellular carcinoma (HCC) [18].
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The upregulation of hsa-miR-182 and hsa-miR-183 and the downregulation of hsa-miR-143 were found in bladder urothelial carcinoma compared to matched histologically normal urothelium in our Real-Time qPCR evaluation.
Cofilin is found in bladder cancer cell lines [ 30].
However, good clinic efficacy has not been found in bladder cancer [ 6– 8].
An overall TSC1 mutation frequency of ∼14.5% is found in bladder cancer (24) (Platt et al., in preparation) and missense mutations comprise 26% of mutations found to date.
Although altered expression of oncogenes, tumor suppressors, and other markers have been found in bladder cancer [ 6], the prognostic utility of currently available biomarkers remains limited, and they are not routinely incorporated into clinical practice.
As a consequence of inflammation, products of mast cell degranulation such as tryptase can be found in the urine of both bladder cancer and cystitis patients [ 8].
Although Lkb1 was not previously linked with bladder cancer and very few Lkb1 mutations were found in human bladder cancer [29], this kinase is a known regulator of TSC1/2 complex via AMPK and subsequent suppression of mTOR [6].
Our present findings indicate that in addition to LYVE-1-positive lymphatic endothelial cells, during bladder cancer development, LYVE-1 positive macrophages were found in the bladder detrusor muscle isolated from SV40- lacZ mice.
To date, inflammasome components have been found in the bladder, prostate, and kidney and have been shown to be activated in response to several infectious and noninfectious insults.
After micturition, no urine residue was found in the bladder.
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