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B-cell aggregates were identified in some samples, which were reminiscent of the ectopic lymphoid tissue that can be found in active rheumatoid synovium [ 51].
Of the subsequently activated family members, the collagenases MMP-1 and MMP-13, the gelatinases MMP-2 and MMP-9, the stromelysin MMP-3 and the membrane-type MMPs can be found in active RA synovium.
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Increased glutaminase (glutamate-producing enzyme) expression in activated immune cells was found in active MS lesions [3].
Furthermore, in these patients, the levels of MPO-ANCA were dependent on disease activity, with high levels being found in active phases of the vasculitic disease [ 15].
Intense angiogenesis has been found in active pulmonary tuberculosis lesions.
Increased levels of peroxynitrite are found in active multiple sclerosis lesions [64].
The presence of active TrPs indicates sensitization of muscle nociceptors in both TMD and FMS since high levels of neuroactive mediators [12, 13] and lower pressure pain thresholds [34 37] have been found in active TrPs.
The presence of active TrPs indicate sensitization of peripheral muscular nociceptors since high levels of chemical mediators [33, 34] and greater mechanical hypersensitivity [35, 36] have been found in active TrPs.
Although, both residues, T and S, have been found in active ATPases, the detailed catalytic consequences of their preference in most NLR proteins remains undefined.
The silencing histone mark H3K9-me3 also bound to methylated and unmethylated rRNA promoters to an equal degree, indicating that H3K9-me is found in active chromatin [24].
With the exception of I571C only hydrophobic residues were found in active variants.
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