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Similar pattern can be found for mutagenicity.
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No correlation was found between urinary mutagenicity and 4-ABP-DNA or BPDE-DNA adducts formation (data not shown).
However, no significant difference in mutagenicity was found between the two oxidants.
Mutagenicity was found in half the NDELA-containing samples but was not related to nitrite or NDELA content.
These PAHs and PAH derivatives found in the coal smoke exhibited strong mutagenicity, and the subfractions containing alkylated three- and four-ring PAHs were found to contribute to most of the mutagenicity in the PAH fraction of coal combustion particles (Chuang et al. 1992a).
In previous mutagenicity assay studies, DNPs, especially 1,8-DNP, were found to be powerful direct-acting mutagens.
Nonetheless, its mutagenicity has been found to be modest and typically detected only at high exposure concentrations.
However, it was found that in general, all the samples showed mutagenicity responses from three- to tenfold greater than negative control, thus representing significant mutagenicity indicating the presence of frame-shift mutagens in the water samples.
More than 90% of the total gas (C8-C18) and particulate direct acting Ames assay mutagenicity (TA 98) was found in the particulate phase.
The overall efficiency of this method depends essentially on the mutagenicity of ENU, which was found to be both strain and dose dependent [ 5- 7].
30 There is no evidence for the mutagenicity of SM and no evidence of teratogenicity was found in rats treated with different doses of SM. 17, 34 SM is classified as a carcinogen by the International Agency for Cancer Research.
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