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Future studies are needed to determine the optimal timing and methods for ARPV use; these should be followed by randomized trials to confirm safety and document the effects of APRV on patient-centered outcomes.
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This was followed by randomized controlled trials demonstrating he was of little use.
In this study, open-label treatment was followed by randomized treatment withdrawal; no clinically relevant safety signals were associated with the abrupt discontinuation of LDX [ 36].
59 This was followed by a randomized phase III placebo-controlled study of pazopanib in previously treated STS patients that showed a statistically significant improvement in PFS, leading to the recent approval.
This initial study of epratuzumab in SLE was followed by two randomized controlled phase 3 trials - SL0003 (ClinicalTrials.gov NCT00111306) and SL0004 (Clinical-Trials.gov:NCT00383214) - in moderate and severe SLE patients.
A 12-week lead-in with liraglutide plus metformin was followed by 26-week randomized period in which subjects not reaching HbA1c <7.0% during the lead-in either added insulin detemir or stayed on metformin plus liraglutide.
These studies have been followed by both non-randomized retrospective studies and prospective controlled trials in different surgical populations to test if triclosan-coated sutures reduce SSIs.
The ensiling study was followed by a 6-wk randomized complete block design feeding study using 12 dairy heifers (initial BW of 213.8 ± 3.03 kg) with 3 diets.
This was followed by a 4-week, randomized, placebo-controlled, parallel-group phase during which patients continued to receive either lanthanum carbonate at the titrated dose, or a matched dose of placebo.
The earlier trial was followed by a multi-centre randomized trial that compared infliximab (given as a single infusion at low dose [1 mg/kg] or high dose [10 mg/kg]) with placebo in 73 patients with active RA [ 8].
This was followed by 5 blocks of randomized trials: no stimulus, startle stimulus (120 dB), 72 dB prepulse+120 dB startle, 84 dB prepulse+120 dB startle, 90 dB prepulse+120 dB startle.
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