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The set of Mot1CTD orientations (n = 20,000) was generated using RANCH, part of the EOM package (Petoukhov et al., 2012) in a 'compact' mode, where Mot1NTD TBP NC2 module was assumed to be flexibly linked to Mot1CTD via the eight amino acid linker (residues 779 786, not present in the atomic models).
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The second subdomain of the HCV helicase is flexibly linked to the remainder of the NS3 protein and could undergo rigid-body movements during the unwinding of double-stranded RNA.
Structural studies indicate that this C terminal region of the tRNA synthetase folds into a compact domain that is flexibly linked to the rest of the structure.
In an alternative model, based on DC-SIGN, CRDs that bind restricted oligosaccharide motifs are flexibly linked and able to accommodate the disposition of these glycans on viral surfaces [ 59].
In the shear crystallized regions, the polymer chains are oriented along the flow direction and the naphthalene planes that are flexibly linked together along the polymer chain tend to be oriented parallel to the broad surfaces of the part.
One of the unexpected findings of the first structures of hUPP1 was the discovery that the domains of the enzymatic dimer are flexibly linked, allowing an interdomain motion from an "open" ligand-free conformation to a "closed" catalytically-active structure [20].
The structures of both SUD-M (previously determined) and SUD-C (from the present study) are maintained in SUD-MC, where the two domains are flexibly linked.
About 30% glycosyltransferase consist of two closely abutting β/α/β Rossmann domains, 20% consist of two β/α/β Rossmann domains that face each other and is flexibly linked.
However, it is clearly flexibly linked to the central polymerase core, as revealed by its lack of density in one 3D class of the EM map.
Radio links can be installed with relatively small costs, and they can be flexibly adapted to changing needs.
The modules can be flexibly delivered to fit within the school timetable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com