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List of SNPs inferred to be fixed for alternative alleles between dogs and wolves.
In the line cross method used here, founder lines are assumed to be fixed for alternative alleles and QTL found explain the genetic variation between the F0 lines [ 19].
This program follows the approach of Haley et al. [ 4] and uses information of multiple linked markers, which may or may not be fixed for alternative alleles in the breeds.
The QTL analysis was performed using the QTL Express software [ 10], which implements the linear regression method of Knott and Haley [ 11] assuming the founder lines to be fixed for alternative alleles at the QTL loci.
A fixed QTL allele model, in which genetically distinct founder lines (MS and LW pigs in this case) were assumed to be fixed for alternative alleles at the QTL affecting the trait of interest, was used for the QTL scan analyses (Haley et al. 1994).
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The additive eQTL coefficient ca was derived assuming that the parental breeds were fixed for alternative eQTL alleles [21].
The lines were fixed for alternative alleles, providing perfect segregation information.
One of the strongest assumptions in this approach is that the original populations are fixed for alternative alleles or at least segregating for multiple different alleles.
Breed of origin probabilities were derived assuming that the parental breeds (i.e., Duroc and Pietrain) were fixed for alternative QTL alleles [ 18].
arabiensis are fixed for alternative arrangements of the Xag inversion which covers ~60% of the X chromosome (Cohuet et al. 2008; Neafsey et al. 2010).
By searching for soft sweeps in the Virginia lines, we showed that approximately 100 genomic regions have been fixed for alternative alleles in the high-weight and low-weight selected lines after 50 generations of selection (Johansson et al. 2010).
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