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Third, deleterious shorter deletions and rare larger insertions may be fixed by drift and selection in the process of speciation and population differentiation [16].
Like any novel mutation, indels could be fixed by drift, but any changes to a flexible linker that alters the activity of the gene product to produce an advantageous variant would be fixed by natural selection.
Authors' response: Some neutral sequences may indeed be fixed by drift alone.
Alternatively, it may mean that these changes could only be fixed by drift in the permissive cell line environment.
Furthermore, it cannot be demanded that every change is selectively advantageous because neutral or even slightly deleterious mutations can be fixed by drift, especially, in small populations [ 9, 14].
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Another objection to adaptationist methods from Gould and Lewontin that has persisted as a criticism of behavioral ecology is that these methods do not allow scientists to consider non-adaptationist explanations for the traits to which they are applied, such as whether those traits were fixed by drift or are simply side effects of other traits (i.e. whether they are "spandrels").
This unique duplication is fixed by drift.
One approach is to estimate the magnitude of heterosis, the increased fitness of progeny derived from crosses between populations relative to crosses within populations caused by the heterozygous masking of deleterious recessive or nearly recessive alleles that have been fixed by drift within populations.
In these scenarios, the duplication itself is not subject to positive selection, and may be fixed by genetic drift.
They suggested that purifying selection was intense in large populations, essentially precluding fixation of significantly damaging mutations, whereas mutation with substantial damaging effects could be fixed by random drift in small populations.
New TEs insertions could thus be fixed by genetic drift, which would lead to an increase of the genome size in the microsporidian species where they occur and offset genome reduction processes.
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