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Models will be fitted using generalised estimating equations (GEEs) to allow for clustering of multiples, with results presented as the mean difference and 95% confidence intervals (CIs) calculated from sandwich estimates of standard errors.
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Parameters, whose coefficients represented incident HIV infections in a given year, were fitted using generalised linear regression models.
Population-averaged models were fitted using generalised estimating equations (GEE) to adjust for the effect of facility.
Population-averaged panel-data models were fitted using a generalised estimating equation approach.
Therefore, a generalised linear model was fitted using a gamma distribution and log-link function.
Then, multivariable generalised additive models were fitted using the procedure GAM of the statistical software package R (R Foundation, Vienna, Austria).
All generalised estimating equation models were fitted using an exchangeable correlation structure and robust SE.
To assess change in infection rates over time, and to determine whether this varied between pruned and unpruned trees, a Generalised Estimation Equation (GEE) model was fitted using PROC GENMOD.
The fixed effects model assumes that there is no between study heterogeneity and is computationally straightforward to fit using generalised least squares because all within-study covariance matrices are regarded as known.
The outputs from models fitted using a Generalised Linear Model approach were then incorporated into an individual-based simulation model of plant spread to investigate the invasion potential in different habitats using a factorial design of treatments.
21 Dichotomous outcomes such as health resource use were compared between treatment arms, with odds ratios obtained from logistic regression models fitted using the generalised estimating equations method.
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