Parameters for the model were fit by maximum likelihood.
Models were fit by maximum likelihood (Laplace Approximation) using a poisson error distribution.
To evaluate associations with adiposity, linear mixed-effects models were fit by maximum likelihood with robust standard errors separately for %DBV and ADBV.
Nevertheless, the duplication model is clearly a better fit for the data as its AICs were so much lower for all three trees when the ancestral chromosome counts were fit by maximum likelihood.
Models were fit by maximum likelihood and model reduction was performed by removing least significant terms and comparing the Akaike information criterion (AIC) value of more complex vs simplified models (Akaike, 1973) until only significant terms were left.
We used piecewise exponential survival models with 3-month increments as the time interval, allowing for a new baseline incidence rate at each 3-month interval, and the models were fit by maximum likelihood.
A linear mixed-effects model was fit by maximum likelihood with clinic included as a random effect and empirical ("robust") standard errors to allow for correlated outcomes within clinics.
The parameters of the ISOpure model, which include the individual cancer and normal profiles and the reference cancer profile, are fit by maximum a posteriori (MAP) estimation in the statistical model (equations 3 to 9) that encodes the ISOpure assumptions.
This limiting behavior is the basis for estimators of the form (Habier et al. 2007) (2) G ^ = θ XX ′ where X is the n× m genotype matrix for m markers and n lines, and the proportionality constant θ is fit by maximum likelihood (or REML).
Matérn, spherical and exponential variogram models were fitted by maximum likelihood to a set of log10(K) observations made on a regular grid at Broom's Barn Farm, Suffolk, England.
