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A longer-term study would be extremely problematic to carry out with this system because of changes in resident composition through time (although for a different approach see [21], [22]), but might reveal different patterns.
31 Given the lack of an objective and widely accepted tool for scoring obstetric risk, it would be extremely problematic to incorporate this factor when matching two cohorts.
"Given the health end points including cancer, cardiovascular disease, neurological, immunological, and developmental disorders, and allergic airway disease including asthma, it will be extremely problematic to accurately assess the true impact of expanded goods movement in coming decades on the health of exposed populations".
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The mechanical shark proved to be extremely problematic during the filming - not to mention being over budget and past schedule.
Mr. Page said it could be "extremely problematic" for some agencies to identify further cuts, on top of the reductions they have already made, without resorting to layoffs.
An attorney for the challengers said it would be extremely problematic for a religious nonprofit to switch from a self-insured plan to an insured plan.
This can be extremely problematic in future litigation, as the shock or concern may lead to emotional and negative reactions to the claim.
High throughput techniques have shown that each individual carries a large number of genomic variations of unclear significance and for some of these variations, especially if found in isolated patients and in the absence of functional studies, the establishment of their pathogenicity in relation to a specific phenotype may be extremely problematic.
Alston acknowledged that human rights policy could be extremely problematic, but said that was no excuse for the bank's member states to avoid a debate on the issue.
Although this god-given ass-tucker that has been effectively marketed to females (and males, although I'd pay to see a guy buy a pair/wear it) it can be extremely problematic in the romance territory.
This kind of behavior serves to dilute the meaning of Buddhism as a religion and can be extremely problematic for how Buddhism is perceived worldwide.
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CEO of Professional Science Editing for Scientists @ prosciediting.com