A disadvantage of fixed sample design is that the same number of subjects will always be used regardless of whether the true treatment effect is extremely beneficial, marginal, or truly harmful relative to the control arm.
As many an airline bankruptcy demonstrates, it can be extremely hard to survive in a business with high fixed costs, low marginal costs and relatively easy entry.
"I used to be, years ago". And now? "I don't feel I'm represented, to be honest". This is an extremely marginal seat, says Kyle, and if he doesn't get enough votes she will end up with a Conservative MP. "Yes, well, I have to vote for what I believe in," says the woman.
An extranodal marginal-zone B-cell lymphoma within a background of a diffuse inflammatory lymphoid infiltrate may be extremely difficult to diagnose (D'Antonio et al. 2009).
The deficiency of mutual information is that the score is extremely impacted by marginal probabilities of words [13, 14]. 3.
This is an extremely marginal seat, says Kyle, and if he doesn't get enough votes she will end up with a Conservative MP. "Yes, well, I have to vote for what I believe in," says the woman.
When the marginal policyholder is extremely price sensitive this demand effect obviously reduces the providers' ability to increase their markup.
The analytical integration of (4) with respect to the magnitude or phase to get the marginal PDF is extremely difficult or even impossible.
Other official and semi-official figures allege, contradictorily, that Mr Vorobiev is utterly marginal; that he is extremely dangerous; that he is mentally unbalanced; that he is an anti-Semite; and that he is a provocateur sponsored by outsiders.
Pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma are extremely rare diseases, which share features with their corresponding adult types, but show distinct differences in clinical behavior.
