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Therefore, any standard random mutational approach to analyze DNMT1 function would be extremely laborious.
This would be extremely laborious in DNA pool preparation and PCR screening.
Such task can be extremely laborious when the properties of interest physically overlap in the sequence space.
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The process of collecting these data and rendering them to produce the reconstructions is extremely laborious and time-consuming.
Every test sample requires separate recording and the analysis of individual cell tracks in two- or three-dimensional migration systems by time-lapse microscopy is extremely laborious.
Manual annotation of such a large number of metabolites, with multiple identifiers each, is extremely laborious.
This approach can be informative, but is extremely laborious and results in the complete destruction of the fossil.
However, the traditional phenotype-based approach for breeding resistant cultivars is extremely laborious and time-consuming, and is often hampered by difficulty in screening the desired resistant progeny under field or limited inoculation conditions.
Because searching for incongruence in trees is extremely laborious when many sequences are present, the preferred pre-screening approach is to scan large data sets for mosaic signals, which are simply incongruent trees with only three sequences included in each tree.
Historically, the analysis of neuronal morphology has been performed either by sparse labeling methods that are not cell type specific (e.g. the Golgi stain) or by filling individual neurons with a tracer using a whole cell patch electrode, a method that is extremely laborious and not easily adaptable as a survey tool [e.g. ref. 48].
Manually sorting of these articles is extremely laborious task.
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