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For example, methylation patterns may be extremely complex if primary CRCs grow through sequential clonal evolution because each clonal expansion would have a different mitotic age and diversity.
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Although the latter law has come under fire for a number of reasons – it has moved very slowly, it charges an already overtaxed and under-resourced Department of Toxic Substances Control with an enormous new task, and is extremely complex – if nothing else, it has helped to raise awareness among consumers and retailers, and spurred suppliers to look at alternatives.
The use of common statistical tests is in part due to the wide recognition of these tests, but also because it is extremely complex (if not impossible) to perform the correct permutation test when sample sizes, and the number of stratification factors, increase (Knijnenburg et al, 2009).
On the operational level, any attack would be extremely complex.
There is also a practical side: any attempt at reconstruction would be extremely complex.
Grainger says, "It's going to be extremely complex".
This is not checkers; this is mutherfuckin' chess – Technology businesses tend to be extremely complex.
But even if those cautious feelers engender an agreement to talk, actual negotiations would be extremely complex and would likely drag on for years.
AI travel algorithms need to be extremely complex and well trained.
However, the interaction of these factors may be extremely complex.
Both measures are extremely complex, and if the Senate makes substantial concessions, that could unravel the fragile coalition of bipartisan support in the Senate.
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