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In February a parliamentary committee said that it would be "extremely challenging, if not impossible" for Britain to keep its promises to decarbonise without building new power stations.
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For the long-term unemployed (those out of work for six months or more) the situation can be extremely challenging in the US if they don't find work quickly.
Passive assay could be extremely challenging in some scenarios.
"At this level of monetization (or even 5x this level of monetization), it is extremely challenging – if not impossible – for most creators and content owners to realize their creative and professional ambitions if this is the sole manner in which they release their content," he wrote.
This illustrates one of the pitfalls of normalizing gene expression results to another gene – it is extremely challenging, if not impossible, to find genes which are expressed at constant levels across all tissues.
"It was extremely challenging in every way, shape and form.
Five-year follow-up would have been extremely challenging in our study population.
This will be extremely challenging (see what I did there?) if you deal with your ex during this time, but I assure you it will make the conversation go much smoother.
Directing opera would be extremely challenging and extremely tempting".
This would be "extremely challenging" but not impossible.
It is going to be extremely challenging to make this work, especially at the outset".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com