Thus, the positive calcium balance produced by calcium carbonate treatment within 3 weeks cautions against its use as a phosphate binder in patients with stage 3 or 4 CKD, if these findings can be extrapolated to long-term therapy.
First, it examined acute effects of a 1-day exposure to prolonged uninterrupted versus interrupted sitting; thus, implications cannot be extrapolated to long-term exposures.
Third, we only collected data on in-hospital mortality rates; hence, it remains unclear whether our results can be extrapolated to long-term outcomes.
Results on self-reported PA after 12 months were extrapolated to long-term outcomes (i.e. 5-year, 10-year, and lifetime horizon) using the Chronic Disease Model.
Effects on weekly Metabolic Equivalents (MET -hours of PA obtained one year after the intervention started were extrapolated to long-terMET -hours (5-year, 10-year and lifetime hofizons) in terms of health effects and quality-adjusted life years (QALYs) and its effect on healthcare costs, using a comPAter simulatiobtained.
It is suggested that short-term studies should not be extrapolated to predict long-term behavior of the system.
Nevertheless, the results from this study should not be extrapolated to the long-term performance of sequentially annealed HXLPE.
Mathematical models are a key tool to allow results from trials and observational studies of these technologies to be extrapolated to explore their long-term impact in population-based screening programmes.
Additional research with runners is needed to determine if our muscle glycogen and MuscleSound® data from the vastus lateralis in cyclists can be extrapolated to the gastrocnemius muscle in long distance runners.
Finally, the hemodynamic and echocardiographic effects of single doses of riociguat in this exploratory phase 2b study cannot be extrapolated to short-term (weeks) or long-term (months to years) treatment responses.
