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(2) and (3) can be extrapolated to conditions outside the reported range.
The usefulness of these PBPK predictions is critically dependent on having confidence that the PBPK model is not just a set of adjustable parameters but, instead, represents a true "physiologically based model" that can be extrapolated to conditions that are different from those that were used to derive the model parameters.
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Vast amounts of data generated from healthcare and medicine are stored and can be used to explore risk factors and outcomes that could be extrapolated to health conditions.
Kinetic parameters of gaseous hydrocarbon generation for crude oil and asphaltene were obtained by kinetic calculation, and the result can be extrapolated to geological conditions.
However, this conclusion may change for a different range of temperatures and should not be extrapolated to other conditions.
However, it should be taken into account that animals were necropsied at 7 dpi and, therefore, results obtained in regards to ADG cannot be extrapolated to field conditions.
Such an approach would not only be of relevance within the field of cancer, but could also be extrapolated to other conditions as well.
Our study examined the acute effects of hyperglycaemia and/or hyperinsulinaemia and can therefore not directly be extrapolated to chronic conditions such as Type 2 diabetes and other insulin resistance syndromes.
If these considerations can be extrapolated to field conditions at all, in this or another system, they indicate that within a given site we cannot have co-evolution but only adaptive evolution of the antagonist that comes out relatively unharmed.
In situations without minimally disturbed sites and historical data, empirical models derived from associations between biological indicators and human-disturbance gradients can be extrapolated to infer conditions in the absence of human disturbance (Stoddard and others 2006).
This paper focuses on laboratory-scale mechanistic understanding and how this can be extrapolated to in situ conditions as part of the Long Term Diffusion (LTD) project at the Grimsel Test Site, Switzerland.
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