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Evidence on its probable effect can be extrapolated from studies in rodents.
However, since PTMC products have not been directly studied in vitro or in vivo, their toxicities need to be extrapolated from studies examining PTMC's ingredients either alone or in studies using similar ingredients to those found in PTMC products.
Additional parallels can be extrapolated from studies of the W. dermatitidis model; 1,8-DHN melanin, a known virulence factor of W. dermatitidis, was also identified in E. rostratum and could similarly impart resistance to host killing and antifungal drug therapy (Paolo et al. 2006; Al-Abdely 2009; Andes and Casadevall 2013).
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Much of the management for UCS has been extrapolated from studies of endometrial carcinomas and sarcomas.
However mercury's toxicity has never been fully demonstrated by scientific studies, and toxic levels were extrapolated from studies conducted on methyl-mercury's toxicity, which is way more toxic and has a half-life 7 times less than mercury [65].
Marijuana's is a matter of conjecture, since it's been extrapolated from studies with lab rats and other such methods.
The doses were extrapolated from studies of sufentanil and/or midazolam in rabbits or dogs [ 24, 59, 60].
However, these findings have the clear drawback of being extrapolated from studies carried out for different purposes.
Thus, numerous inadequacies exist in the extant literature and much of clinical practice in this area has been extrapolated from studies of inpatients.
Similarly, data used for clinical efficacy in our evaluation has been extrapolated from studies on two SbV, i.e. meglumine antimoniate and SSG.
Most of the information about the epidemiology of BSIs and outcome is extrapolated from studies of hospitalized patients in general hospitals or from studies of patients in University hospitals [ 18] or, more specifically, from studies of neutropenic cancer patients [ 19].
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