Although further studies are needed to clarify the exact mechanism of HIF-1α expression, HIF-1α may be expressed in response to change of cellular microenvironment, especially O2 tension, in the tissue.
AngII, a potent stimulator of cardiomyocyte hypertrophy, may be expressed in response to hypoxia to enhance myocardin expression and cardiomyocyte gene transcription as shown previously in VSMC models [ 23, 24].
In the family of NOS, iNOS was particularly involved in pathological aspects with overproduction of NO, which could be expressed in response to pro-inflammatory agents such as interleukin-1β, tumor necrosis factor-a and lipopolysaccharide (LPS) in various cell types such as macrophages, endothelial cells and smooth muscle cells [21].
Wip1 is a nuclear protein phosphatase that was found to be expressed in response to p53 and to complete a negative feedback loop through inhibition of p53 [29].
The IL1R2 protein is expressed on B cells, monocytes/macrophages and neutrophils [30], and may be expressed in response to many stimuli, including oxygen radicals, IL-4, IL-13, and glucocorticoids [30], possibly explaining the ability of steroids to ameliorate AIED.
While the precise role of A2 is unknown, it is present in low levels in cultured promastigotes and has been shown to be expressed in response to cellular stress, such as increased temperature, as well as in response to stimulation of differentiation [24], [25], [26].
H2-T32/24AS is responsive to only TNFα and TLR3 agonists, whereas HoxA11AS is expressed in response to TLR3 agonists and actually down regulated by TNFα stimulation.
First, a diminished quantity of cachectin mRNA is expressed in response to low concentrations of endotoxin.
These findings establish the utility of mRNA-Seq in identifying uncharacterized transcripts that are expressed in response to Pi stress.
Furthermore, meta-analysis with diverse datasets of genes that are expressed in response to biotic and abiotic stresses as well as hormones treatment was performed.
Therefore, we designed a quantitative-RT-PCR (qRT-PCR) array for detection of more than 50 TFs that are expressed in response to type I IFN (TF ISGs).
