In the mouse genome, both immune system genes and tissue-specific genes are found to be expressed in clusters (Williams and Hurst 2002).
In a similar fashion, the crustacean proneural gene Tl-ASH1 was shown to be expressed in clusters of cells, whereas Tl-ASH2 is expressed later in only a subset of the Tl-ASH-expressing cells [ 24], providing further evidence that Tl-ASH2 is likely to be an ase orthologue.
In well to moderately differentiated tumor samples with low level of CTIP2 expression, Cytokeratin 10 was expressed in clusters (Fig. 3A).
Proneural genes are expressed in clusters of cells and predispose them to a neural fate.
In wild-type and h674 heterozygous embryos (Figure 8A and E), bnl in non-tracheal cells at mid-embryogenesis was expressed in clusters close to the migrating tracheal dorsal branch, visceral branch, lateral trunk and ganglionic branches, as previously reported [6], [12].
In all cases, gal-7 was expressed in clusters, mostly being found inside the mitochondria (Additional file 3: Figure S3).
In our buffer-treated controls, we observed that both CXCR2 and CXCR1 receptors are expressed in clusters on the neutrophil membrane, as described previously (Gray et al, 1997).
DOI: http://dx.doi.org/10.7554/eLife.01832.014 10.7554/eLiFigure32.015 figure 5—figure supplement 1. lef1 is expressed in clusters of interneuromast cells before they become intercalary neuromasts.
Glomeris WntA is expressed in clusters of cells in the ventral neuroectoderm posterior to en expressing cells, at the posterior end of the germ band (weakly) and developing heart [ 33].
In addition, in situ hybridization analyses have shown that well-known markers of the adult mammalian intestinal stem cells, such as leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) and Musashi-1 (Msi-1), are expressed in clusters of intestinal epithelial cells at the climax of metamorphosis, suggesting that the clusters or islets are proliferating adult stem cells.
Nomaksteinsky et al. now show that brn3 is expressed in clusters of mechano- and nociceptive sensory neurons (as identified by coexpression of the neuropeptide Sensorin A in the opisthobranch gastropod Aplysia californica (the California sea slug) and in the pulmonate snail Lymnaea stagnalis.
