Nonetheless, in fish, there is evidence that some constitutively expressed AMPPs, such as piscidins and histone-like proteins, are expressed at microbicidal levels and that they decline with stress.
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All pmps were expressed at two hours.
Transfected Skp2 was expressed at higher concentrations.
oto was expressed at all stages examined.
TauBr, in contrast to TauCl, seems to be an effective microbicidal agent at very low physiologic concentrations <10 μM, even at neutral pH (Marcinkiewicz et al. 2006a, b).
Since CAP, unlike the other polymers listed above, is not soluble at low pH, characteristic for a normal vaginal environment [ 42], micronized forms of CAP had to be used in microbicidal formulations of this compound [ 30- 34].
To evaluate whether the action of the extract was microbiostatic or microbicidal, 20 μl of the microbial culture were removed from wells with concentrations equal to, or higher than, the MIC, inoculated on BHI agar plates, and incubated at 37°C for 24 h.
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