The intracellular, cytoplasmic concentration of IKK α also tended to be expressed at increased levels in cancerous colorectal epithelial cells.
If this were the case, the native BCR gene on the unaffected chromosome 22 would also be expressed at increased levels in resistant cells.
In particular CD40 was suggested to be expressed at increased levels on blood DCs from HIV-infected individuals, as assessed in cross-sectional studies (Barron et al, 2003; Dillon et al, 2008).
Two miRNAs from this location, miR-373 and miR-520c, have previously been shown to stimulate cancer cell migration and invasion in both in vitro and in vivo models and to be expressed at increased levels in metastatic breast cancer [ 43].
For example, PTP4A3, a gene encoding a protein tyrosine phosphatase that has been reported to be expressed at increased levels in aggressive (Molleví et al, 2008) or metastatic (Guzinska-Ustymowicz et al, 2009) CRC, strongly associated with therapy benefit across all three endpoints.
Another pancreatic endocrine marker Ngn3 was expressed at increasing levels throughout the differentiation protocol.
As Ankrd2 is expressed at increasing levels during differentiation, the major transcriptional changes were found in Ankrd2 KO myotubes, where the expression of many crucial NF- κB-inducible genes, including the pro-inflammatory cytokines Tnf α, Il1 β, and Il6, was increased (see Supplementary Dataset S1).
The observations that Eef1a2 transcripts are expressed at increased levels in the majority of primary PCT but in a smaller proportion of primary MM indicate that the mechanisms governing aberrant expression and possible contributions to transformation of plasma cells are likely to differ between the species.
However, DNA methyltransferase was expressed at increased levels in tumor tissue compared to the corresponding normal colon tissue.
† Positive log ratios (LR) indicate genes that are expressed at increased levels in the high line flies.
