Interestingly, we found SDF-1α expression and eNOS NO cascade to be expressed at a low level at the wound site in db +/db + mice; RLX treatment succeeded in reversing these defects.
Thus, genes with high tissue specificity in expression (indicating a more specific function) generally appeared to be expressed at a lower level than genes with more even expression levels across the sampled tissues (indicating a more general function).
Remarkably, high levels of these activating acetylations are not significantly correlated with gene expression, while H3K27 tri-methylated genes tend to be expressed at a low level.
Although ribosomal proteins are assumed to be in 1 1 stoichiometry (Voynow and Kurland 1971; Hardy 1975), global chromosomal differences in expression would cause X-linked ribosomal genes to be expressed at a higher level than autosomal genes.
When events are cancelled, universities will often try and secure other opportunities for the speakers' views to be expressed at a subsequent event in a safer environment, to ensure that free speech is not compromised.
With gene therapy, genes encoding therapeutic growth factors can be expressed at a high level in the injured site for an extended period of time.
Stable transfection of H9C2 cells with a plasmid producing a tetracycline transactivator protein allows foreign genes to be expressed at a level tightly controlled by the concentration of tetracycline in the culture medium.
As Otx2 seems to be expressed at a lower level there, the Cre recombinase might also be expressed at a low level which would decrease the fraction of cells in which it will act.
Interestingly, many of these genes also appeared to be expressed at a lower level in all the other organs (Fig. S2A).
For example, Msx1 was found to be expressed at a very high level (1098 tpm) in NCAM+ cells but was absent in undifferentiated hESCs.
The two genes appear to be expressed at a very low basal level and their roles in cell wall metabolism, if any, remains to be established.
