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SVCT2 was shown to be expressed and functionally active in tanycytes - hypothalamic glial cells [20], brain stem stem cells, neuroblastoma cells, embryonic and adult neurons of different subtypes in rats and mice [7], [19], [24], [37].
This system utilizes a mutant strain of Drosophila in which the 2 native receptors of the ab3A neuron have been deleted, this creates a nonresponsive Δab3A in which other receptors can be expressed and functionally tested.
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Without further investigation on opsin expression, we cannot rule out the possibility that other opsins are expressed and functionally involved in erythrophore photoresponses.
We and others have shown that PPARγ is expressed and functionally active in chondrocytes and that PPARγ activators modulate the expression of several genes considered essential in the pathogenesis of OA.
Thus, in the absence of further empirical work, it remains possible that these isoforms are expressed and functionally relevant.
However, it is not clear whether these chimeras are expressed (and functionally relevant) or whether they are simply generated as a nonadaptive byproduct of recombination between identical repeats.
It is expressed and functionally active in a number of different cell types, including vascular smooth muscle cells [ 4], endothelial cells [ 5], cardiac fibroblasts [ 6] and myocytes [ 7].
Second, neurofibromin is expressed and is functionally important in RAS regulation in B lymphocytes [ 25, 26] in mouse models of NF1.
Neurofibromin (the protein product of NF1) is expressed and is functionally important in B lymphocytes (the cells transformed by Epstein-Barr virus (EBV) into LCLs) [ 8].
Our data clearly demonstrate that CFTR is expressed and it is functionally active as a Cl− channel in monocyte-derived macrophages isolated from healthy donors.
Altogether, these results suggest that at least in humans, PPP1R2P1 is expressed and might be functionally relevant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com