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Assays performed with recombinant HEK293 cells in which endogeneous putative water channels might be expressed and functional, could not rule out the possibility that the Rh proteins can transport water [21].
Taken together hiPSC-CMs recapitulate functional key Ca2+ handling proteins that have been shown to be expressed and functional in mouse ESC-CMs [25], [26], [33], hESC-CMs [18], [19], [30], and adult cardiac tissue [9].
These data support the notion that targets of toceranib may be expressed and functional in these tumor types.
The high conservation of MIR168b suggests that it could be expressed and functional, even though, up to now, no experimental evidence has been reported.
Indeed, abdA has been shown to be expressed and functional in several distinct tissues and cell types, including abdominal neuroblasts and the female genital disc [ 50, 51].
It is also now clear that VEGF receptors can be expressed and functional on cancer cells, indicating that anti-VEGF treatment strategies may have direct antitumour effects (Wedam et al, 2006).
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Thus, ß-galactosidase activity is present only in tissues where Cre recombinase is expressed and functional.
In this study, we have provided evidence suggesting that there are four distinct IGF genes in the zebrafish genome and all four IGF genes are expressed and functional.
It was recently demonstrated that in both mouse [25], [26] and human [18], [27] ESC-CMs an IP3-releasable Ca2+ pool is expressed and functional.
The remaining issue is which (if any) of the linked genes are expressed and functional.
However, additional experiments are required to clarify whether hemolysin III and the agr operon are expressed and functional in W. ceti.
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