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Nevertheless, this observation that depletion of ERα sensitizes tumorspheres to 4-OHT may be explored to target TICs.
Combination of a M. tuberculosis specific IFN-γ ELISpot with a M. tuberculosis specific IL-2 ELISpot significantly improved the identification of individuals with the highest risk of recent M. tuberculosis infection and is a promising method that should be explored to target tuberculosis preventive chemotherapy.
Similar approaches should be explored to target CIN and other cancer-associated forms of genomic instability.
Therapies should be explored to target these preclinical cardiac changes to modify cardiovascular risk associated with Type 2 diabetes and NAFLD.
The driving pathophysiological mechanisms by which tumor initiation and progression occur during the process of hepatic carcinogenesis needs to be explored to target pathways, which are attractive for therapeutic intervention.
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Thus, quite a number of nanoparticular vaccine delivery systems based on different biomaterials have been explored to target the PRRs on DCs and mimick the pathogen properties to enhance immune responses (Demento et al., 2011; Park, 2014).
This editorial highlights a diverse array of approaches currently being explored to target cognitive dysfunction due to aging and/or Alzheimer's disease.
Various strategies are currently being explored to target these important regulatory molecules and their downstream effectors for potential use in cancer treatment [214]– [214].
E-selectin is currently being explored to target therapeutics to CTCs under blood flow conditions, due to the rapid, force-dependent binding kinetics between E-selectin and selectin ligands on CTCs (66) (Fig. 3).
Aspects of health behavior theory other than perceived risk need to be explored to help target efforts in the primary prevention of diabetes.
Furthermore, the role of social support and other potential variables more highly associated with QOL should be explored to effectively target QOL outcomes specific to diagnosis and treatment.
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