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The combination of lanreotide and targeted therapies, mainly everolimus and sunitinib, is widely used in clinical practice without unexpected toxicities and suggests efficacy that should be explored in randomized prospective clinical trials.
Whether this higher and more consistently delivered dose early in a patient's course of critically illness translates into better metabolic homeostasis remains speculative and should be explored in randomized trials, despite prior trials showing no significant impact on survival or recovery by delivered dose [ 13- 15].
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Thus, the role of Candida in the bile should be explored in a randomized trial.
The in-vitro and in-vivo data available suggest that N-acetylcysteine, a drug with low toxicity used to liquefy the pulmonary secretion in pneumonia and to protect the liver after paracetamol poisoning, should be explored in a randomized trial concerning its ability to lower the speed of progression of amyotrophic lateral sclerosis in humans.
Clearly, this should be explored in a prospective randomized clinical trial as it is currently being performed in patients after renal transplantation in our transplant center.
Sound will be explored in many guises.
This issue will be explored in 5.3.
These will be explored in turn.
In addition, mTOR has been explored in two randomized trials (BOLERO-2 and TAMRAD) as a potential therapeutic target for overcoming endocrine therapy resistance [ 63].
18, 19 The role of panitumumab in combination with anti-angiogenic drugs has also been explored in a randomized phase III study (Panitumumab Advanced Colorectal Cancer Evaluation, (PACCE)).
However, dosage adjustment is not necessary for patients taking moderate CYP 3A4/5 inhibitors, such as diltiazem, verapamil, erythromycin, or grapefruit juice. 1 The pharmacokinetics of saxagliptin were explored in two randomized, double-blind, placebo-controlled, sequential ascending-dose trials.
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